منابع مشابه
Therapeutic Substitution and Formulary Systems
T he practice of therapeutic drug substitution has become common throughout the United States, often without the awareness of many physicians. It occurs to some extent in more than 52% of the nation’s acute care hospitals and more than 30% of health maintenance organizations (HMOs) (1, 2). Therapeutic substitution entails dispensing a drug different in chemical structure from the one originally...
متن کاملTherapeutic substitution: guilty until proven innocent.
The “evidence” is evidence-based medicine, which defines therapeutic efficacy and safety for specific pharmacological interventions. The “weight” or power of evidence in support of treatment is maximum when determined by large, placebo-controlled, randomized trials (Level A), less definite when based on smaller randomized trials and/or clinical registries (Level B), and least reliable when depe...
متن کاملCannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism.
The anxiety-reduction model often utilized to explain initiation and perpetuation of episodic drinking was found inadequate to explain motivation for alcohol use by the alcoholic. Euphoria and elation were manifest only during the initial phases of intoxication. Prolonged drinking was characterized by progressive depression, guilt, and psychic pain. These unpleasant affects, however, were poorl...
متن کاملAugmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Although humanized antibodies have been highly successful in the clinic, all current humanization techniques have potential limitations, such as: reliance on rodent hosts, immunogenicity due to high non-germ-line amino acid content, v-domain destabilization, expression and formulation issues. This study presents a technology that generates stable, soluble, ultrahumanized antibodies via single-s...
متن کاملImpact of Cost Sharing on Therapeutic Substitution: The Story of Statins in 2006
BACKGROUND Cost sharing is widely used to encourage therapeutic substitution. This study aimed to examine the impact of increases in patient cost-sharing differentials for brand name and generic drugs on statin utilization on entry into the Medicare Part D coverage gap. METHOD AND RESULTS Using 5% Medicare Chronic Condition Warehouse files from 2006, this quasi-experimental study examined pat...
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ژورنال
عنوان ژورنال: Circulation
سال: 2003
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000103637.50536.cc